Title of article
Changing trends in drug resistance among typhoid salmonellae in Rawalpindi, Pakistan
Author/Authors
Butt, T. Armed Forces Institute of Pathology - Department of Microbiology, Pakistan , Ahmad, R.N. Armed Forces Institute of Pathology - Microbiology Department, Pakistan , Salman, M. Armed Forces Institute of Pathology - Microbiology Department, Pakistan , Salman, M. National Institute of Health, Pakistan , Kazmi, S.Y. Armed Forces Institute of Pathology - Microbiology Department, Pakistan
From page
1038
To page
1044
Abstract
We analysed the record of blood cultures carried out at the Armed Forces Institute of Pathology, Rawalpindi between 1996 and 2003. We isolated 477 Salmonella typhi and 410 S. paratyphi A from blood of patients suffering from typhoid fever. We observed a significant shift in the distribution and antimicrobial susceptibility of typhoid salmonellae. The isolation rate of S. typhi fell significantly while S. paratyphi A is emerging as a major pathogen. Resistance to conventional antityphoid drugs in S. typhi decreased dramatically from 80% to 14%, while in S. paratyphi A resistance increased from 14% to 44%. Susceptibility to the fluoroquinolones decreased in both. No resistance to third generation cephalosporins was detected
Journal title
Eastern Mediterranean Health Journal
Journal title
Eastern Mediterranean Health Journal
Record number
2637577
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