Ketogenic diet Update and application

The ketogenic diet is a high-fat, low-carbohydrate, and adequate-protein diet for the treatment of intractable seizures inchildren, initially introduced in 1921 to mimic the biochemical changes associated with fasting. The diet is individuallycalculated and rigidly controlled, requiring a comprehensive medical team approach. Although there are adverse, aswell as, beneficial effects, several studies have proved its tolerability and efficacy in children with medically refractoryepilepsy. Children must be carefully selected, monitored, and followed, and the parents must be committed. The divisionof Pediatric Neurology at King Faisal Specialist Hospital Research Center in Jeddah is one of very few centers thatprovide this treatment option in the Middle East. Over the last 2 years, 8 children with intractable epilepsy were placed onthe ketogenic diet in our center. Overall, 38% (3/8) reached accepted efficacy ( 50% seizure reduction), which is lowerthan the 50% efficacy in published literature. Many issues and problems arose in the provision and compliance with theketogenic diet, many of which were unique to our culture. It is critical that this treatment is provided to highly selectedchildren with committed parents