Author/Authors :
Borhani-Haghighi, Afshin shiraz university of medical sciences - Departments of Neurology, شيراز, ايران , Samangooie, Shahdokht shiraz university of medical sciences - Internal Medicine, شيراز, ايران , Ashjazadeh, Nahid shiraz university of medical sciences - Department of Neurology, شيراز, ايران , Nikseresht, Alireza shiraz university of medical sciences - Departments of Neurology, شيراز, ايران , Shariat, Abdolhamid shiraz university of medical sciences - Departments of Neurology, شيراز, ايران , Yousefipour, Gholamali shiraz university of medical sciences - Departments of Neurology, شيراز, ايران , Safari, Anahid shiraz university of medical sciences - Departments of Neurology, شيراز, ايران
Abstract :
Objectives: To determine the prevalence, clinicalmanifestations, and laboratory features of Neuro-Behçet’sdisease.Methods: This prospective study was carried out in theBehçet’s Research Clinic in Shiraz (south-west Iran)and included the patients referred from 1990-1999. Thepatients’ clinical records, images, CSF analyses, andelectrodiagnostic studies were reviewed.Results: Eighteen (15 males and 3 females) out of 690Behçet’s patients (2.6%, 95% CI = 1.4-3.8%) werefound to have neurological involvement. The mean ±standard deviation age of these patients was 34.7±8.6years. All fulfilled the criteria of the International StudyGroup of Behçet’s Disease. Central nervous systeminvolvement was more common than peripheral nervousABSTRACTsystem manifestations. Headache, weakness, tingling, andnumbness were the most common symptoms. Hyperreflexia,upward plantar reflex, and somatosensory findings were themost frequent signs. Hemispheral and brainstem strokelikesyndromes and cerebral venous thrombosis were themajor neurologic presentations. There were also cases ofmyelitic, pure meningoencephalitic, amyotrophic lateralsclerosis-like, multiple sclerosis-like, and Guillain Barresyndromes.Conclusions: Neuro-Behçet’s disease must be consideredin the differential diagnosis of stroke in young adults,chronic meningitis, intracranial hypertension, multiplesclerosis, myelopathies, and peripheral neuropathies.
