Author/Authors :
Kavakli, Ahmet Firat University - School of Medicine - Departments of Anatomy, Turkey , Kose, Evren Firat University - School of Medicine - Departments of Anatomy, Turkey , Kus, Ilter Firat University - School of Medicine - Departments of Anatomy, Turkey , Zararsiz, Ismail Firat University - School of Medicine - Departments of Anatomy, Turkey , Akpolat, Nusret Firat University - School of Medicine - Pathology, Turkey , Sarsilmaz, Mustafa Firat University - School of Medicine - Departments of Anatomy, Turkey
Abstract :
Objective: To investigate possibleneuroprotective effects of dietarysupplementation of fish oil in brain ischemiareperfusion(I/R).Methods: This investigation took place in theExperimental Research Unit, Firat University,Elazig, Turkey, from January-February 2006.The study was carried out on 12 male Wistarrats; divided into 2 groups: I/R (control)and I/R + ω-3 essential fatty acids (EFA)(experiment). The rats in the I/R groupreceived only ordinary rat food before middlecerebral artery (MCA) occlusion. The I/R + ω-3 EFA group received omega-3 fatty acid dailyvia intragastric gavage (300 mg/kg Marincapcapsule) with normal food before MCAocclusion for 30 days. Structural alterationsin the brain tissues were semi-quantitativelyanalyzed (0: absent, +: slight, ++: moderate,+++: severe).Results: There was evident severe ( +++) edema,vacuolization, and eosinophilic degenerationin the I/R group, while only slight (+) edemaand eosinophilic degeneration in the I/R +ω-3 EFA group in which no vacuolizationwas determined. These findings are consistentwith the available studies in this field.Conclusion: Results from this studyindicate the beneficial effects of ω-3 EFAsupplementation in prevention of I/R -induced damage in rats.
