Author/Authors :
Isik, Berrin Gazi Üniversitesi - Faculty of Medicine - Department of Anesthesiology and Reanimation, Turkey , Arslan, Mustafa Gazi Üniversitesi - Faculty of Medicine - Department of Anesthesiology and Reanimation, Turkey , Özsoylar, Özgür Gazi Üniversitesi - Faculty of Medicine - Department of Anesthesiology and Reanimation, Turkey , Unal, Yusuf Gazi Üniversitesi - Faculty of Medicine - Department of Anesthesiology and Reanimation, Turkey , Demirel, Cengiz B. Gazi Üniversitesi - Faculty of Medicine - Department of Anesthesiology and Reanimation, Turkey , Çekmen, Nedim Gazi Üniversitesi - Faculty of Medicine - Department of Anesthesiology and Reanimation, Turkey , Kurtipek, Ömer Gazi Üniversitesi - Faculty of Medicine - Department of Anesthesiology and Reanimation, Turkey
Abstract :
Objective: To determine the effect ofintraperitoneal (ip) nicotine on the recovery ofrats receiving general anesthesia compared withplacebo.Methods: The placebo controlled experimentalstudy was conducted in the Faculty of Medicine,Gazi University, Turkey, between April andMay 2005. Twenty-one male and 21 female ratswere randomly divided into 3 groups. Group C(n=14), comprising a female group CF (n=7), andmale group CM (n=7) received ip 0.9% sodiumchloride (NaCl), group P (n=14), comprising afemale group PF (n=7), and male group PM (n=7)received ip propofol 150 mg/kg, and group NP(n=14), comprising a female group NPF (n=7),and male group NPM (n=7) received 0.4 mg/kg ip nicotine followed by 150 mg/kg propofolafter 15 minutes. For the evaluation of recoveryperiod, tail pinch test was used, and for cognitiveperformance, the radial arm maze test was used.Results: The number of entrances and exitsdecreased in group P significantly compared togroup C (p 0.05), and the decrease in group PFwas higher than it was in group PM. Entrance andexit in group NP increased significantly comparedto group P (p 0.05). The increase in entrance andexit in group NPF was much higher compared togroup NPM. The recovery period in group NP wassignificantly shorter than in group P (p 0.05).Conclusion: The ip administration of nicotine inrats shortens the recovery from propofol anesthesiaand improves cognitive performance.
