Author/Authors :
Al-Nimer, Marwan S. Al-Mustansiriya University - College of Medicine - Department of Pharmacology , Hussein, Ismail I. Al-Mustansiriyia University - College of Medicine - Departments of Physiology , Lasso, Warda S. Baghdad Teaching Hospital - Department of Ultrasound, Iraq
Abstract :
Objectives: To assess subclinical atherosclerosisin subtypes of hypertension using lipid profile as abiomarker and B mode ultrasonography of the carotidarteries.Methods: Ninety-six subjects (49 females and 47males) aged 42-78 years were recruited from the vascular Doppler unit at Baghdad Teaching Hospital,Baghdad, Iraq from January to June 2008. They were grouped into normotensive (group I), isolated systolic hypertension (group II), isolated diastolichypertension (group III), and combined systolic and diastolic hypertension (group IV).Results: Subclinical at herosclerosis was observed ingroups III and IV in terms of significantly low levelsof high-density lipoprotein, high levels of low-density lipoprotein, and high at herogenic index. The mean in tima media thickness was significantly increased with transition from group I to group IV in all carotidarteries, and the mean resistive index value of each carotid artery in group IV was significantly higher than that of group I. Carotid plaque was demonstratedin a significantly higher percent in group IV (12 outof 15) followed by groups III (14 out of 31) and II (1out of 30).Conclusion: Lipid profile and high resolution Bmodeultrasonography of the carotids are goodpredictive measures of subclinical atherosclerosis.Isolated diastolic hypertension and combined systolicdiastolic hypertension accounts for early subclinical atherosclerosis compared with isolated systolic hypertension.
