Study the Effect of Hyperthyroidism on Heart Function by Using BNP as Indicator

The aim was made to specify the effect of hyperthyroidism on B-type natriuretic peptide (BNP) level. Twenty patients with hyperthyroidism, 20 patients with hyperthyroidism treated with (35) mg Carbimazole, 12 patients with hyperthyroidism associated with heart failure and 20 healthy participants were included in this study. Serum Triiodothyronine (T3), Thyroxin (T4) and Thyroid stimulating hormone (TSH) have been used for hyperthyroidism diagnosis test, also serum BNP level was measured. The results showed that the mean ± SE of serum BNP was significantly (P 0.05) increased in hyperthyroid group (420.76 ± 83.43) pg/mL and hyperthyroid with heart failure group (728.58±149.06) pg/mL when compared with the control group (23.18 ±10.10) pg/mL. While, no significant (P 0.05) differences between hyperthyroid treated with (35) mg carbimazole group (65.00 ± 16.21) pg/mL and control group (23.18 ±10.10) pg/mL. But, there was a significant (p 0.05) decrease in serum BNP level in hyperthyroid treated with (35) mg carbimazole group when compared with the hyperthyroid group and hyperthyroid with heart failure group. The present study demonstrated that the hyperthyroidism may lead to impaired heart function, and thus the high level of the BNP hormone