Author/Authors :
Yilmaz, N. Gaziantep University - Medical School - Department of Biochemistry, Turkey , Qigek, H.K. Gaziantep University - Medical School - Department of Biochemistry, Turkey , Qelik, A. Gaziantep University - Medical School - Department of Biochemistry, Turkey , Meram, I. Gaziantep University - Medical School - Department of Biochemistry, Turkey , Kocabas, R. Gaziantep University - Medical School - Department of Biochemistry, Turkey , Davutoglu, V. Gaziantep University - Medical School - Department of Cardiology, Turkey
Abstract :
We evaluated 3 new markers for coronary artery disease (CAD) [bilirubin, total homocysteine (t-Hcy) and high-sensitivity C-reactive protein (hs-CRP)] in 319 patients with chest pains divided into 2 groups based on coronary angiography: CAD group (n = 262) and non-CAD group (n = 57). A control group consisted of 50 healthy subjects. t-Hcy had the highest diagnostic value for diagnosis of angiographically documented patients; bilirubin had the lowest. The sensitivities and specificities (based on ROC curves) of bilirubin, hs-CRP and t-Hcy were 70.9%, 50% and 76.8% respectively, and 40.4%, 80.7% and 70.2% respectively. We conclude that serum bilirubin levels cannot identify people at risk of CAD and t-Hcy and hs-CRP may be stronger markers.
