Author/Authors :
Saleh, A. Theodor Bilharz Research Institute - Department of Clinical Chemistry, Egypt , Kamel, L. Theodor Bilharz Research Institute - Department of Clinical Chemistry, Egypt , Ghali, A. Theodor Bilharz Research Institute - Department of Tropical Medicine, Egypt , Ismail, A. Theodor Bilharz Research Institute - Department of Tropical Medicine, Egypt , El Khayat, H. Theodor Bilharz Research Institute - Department of Tropical Medicine, Egypt
Abstract :
To find a reliable, noninvasive method for the diagnosis of cognitive impairment in patients with hepatic cirrhosis we measured serum levels of astroglial S100P and neuron-specific enolase in cirrhotic patients with and without hepatic encephalopathy (HE). S100p levels showed a significant increase in groups with HE stage 1 and 2 compared to both control and cirrhosis patients. However serum neuron-specific enolase levels were not significantly different between the studied groups. S1 OOp levels had a specificity of 91.3% and sensitivity of 51.7% for detection of HE from cirrhosis. Serum S100p may be a useful surrogate marker for the diagnosis of mild cognitive impairment in cirrhotic patients before they progress to more advanced stages of HE.
