The study of variations in lipid profile and GLP-1 enzyme levels of obese in sample of Iraqi population

The present study conducted on 120 males obese and 50 healthy males, their age ranged from 20-50 years. The patients were divided into 3 groups based on Body Mass Index (BMI) and Central Obesity (CO.); it has noticed that there is a significant relation between both indexes. Effect of the obesity on the lipid profile was investigated, the results showed that there is an elevated in TG, TC, LDL-C, VLDL-C and lowered in HDL-C for all three obesity groups compare with control group. Also, Significant differences (P≤0.05) revealed in TG, TC, LDL-C and VLDL-C among three obesity groups and the greatest differences recorded in group III obesity (279.52±1.10, 261.02±1.13, 169.32±1.81, and 55.08±1.33 mg/dl respectively) followed by group II obesity (216.58±1.79, 228.20±1.28, 135.41±1.21 and 40.34±1.17 mg/dl respectively) and then group I obesity (152.00±1.81, 168.47±1.11, 104.33±1.99 and 27.90±1.46 mg/dl respectively). No significant differences observed in HDL-C among groups I, II and III obesity (34.23±1.59, 36.65±1.78, 35.08±1.12 mg/dl respectively). The study included investigate for serum GLP-1 enzyme levels, a lowered in GLP-1 levels was observed in groups I, II and III obesity (39.33±1.31, 35.58±1.87, 35.56±1.66 pM respectively) compare with control (62.50±1.50 pM). Besides having a highly significant correlation (P≤0.01) between GLP-1 level and both indexes (BMI and CO.) in which an elevated in BMI and CO. were correlated to an lowered in GLP-1 level.