An Association Between Celiac Disease Specific Autoantibody and Infertility in Male :Across Sectional Study

Background:The male infertility is considered a health problem ,which attributed to many factors such as genetic ,environmental , previous infections, bad lifestyle and others.these factors have been reported in previous studies.However, this study aimed to determine the effect of anti-tissue transglutaminase antibodies (IgA-tTG)as celiac disease product on the male infertilityObjective: This study was aimed to find out the incidence of celiac disease-specific antibodies, which is known as IgAanti-tissue transglutaminase antibodies (IgA-tTG) in the group of infertile male in Al-Najaf city by across sectional study.Methodology: Seventy six infertile men have been enrolled in this study,which was extended from Jun - August 2014At Fertility Center -AlSader Medical City in Al-Najaf governorate. Ages of patients ranged between (52 – 20) (Mean ± SD) = 31.1 ± 7.18). IgA-tTG studied by using ELIS kit (IBL international company, Germany).The results:Although, the findings of present study showed that there is a high significant difference in sperm concentration between IgA-tTG antibodies positive and negative male infertility patients, but this outcome not means that, these autoantibodies have critical role in the spermatogenesis, thus this results may be due to other factors such as ,growth hormone ,obesity or bad lifestyle ,thus we can see that the correlation between the sperm concentration and the incidence of autoantibodies type IgA against tissue transglutaminase was non-significant with a p value 0.31 , either in patients with normozoospermia or in patients with oligozoospermia. In addition to that the percentage of incidence of IgA- tTGA in the infertile men was 4%.These results have obtained by using statistical mean , standard deviation and chi-sequare.Conclusion: we revealed that IgA-tTGhas no implicated with factors that responsible for infertility in males , thus celiac disease as autoimmune disease may not produce any effectiveness of male reproductive system activity.Recommendations:Investigate other autoimmune disease products that may be contributing to thisdisease.