Effect of iron status on fertility of woman in relation with certain hormones and other parameters

Seventy six subfertile women and thirty fertile women (control group) enrolled in this study. The subfertile women subdivided into two subgroups according to the cause of subfertility: first group ovarian dysfunction (OD) either due to polycystic ovary syndrom (PCOS) or due to other cause (OC) likes anovulation, hyperprolactenemia, premature ovarian failure. Second group: unexplained infertility, their age range (16-40) yr. At day 3 of menstrual cycle (MC) estimation of serum level of multiple hormones like luteinized (LH), follicle stimulating (FSH), estradiole (E2), prolactin (PRL), testosterone, iron status (serum iron, serum ferrtin and total iron binding capacity TIBC) , while at day 13 of MC, estimation of serum levels of LH, serum leptin, glutathione, iron status .Comparison of iron status between fertile and subfertile women at day 13 of MC revealed significant increase in serum ferritin level in women with PCOS. Assessment the serum levels of certain hormones in fertile and subfertile women in those having serum ferritin level less than normal value at day 3 of MC show the following: significantly higher serum testosterone level in PCOS group, also significantly higher serum prolactine level in group of OD due to O.C. as compared with fertile group. Assessment the serum levels of certain hormones in fertile and subfertile women in those having serum ferritin level higher than normal value at day 3 of MC show significantly higher serum prolactine level in group of OD due to O.C. as compared with fertile group. Assessment the serum levels of certain hormones in those having serum ferritin level less than normal value at day 13 of MC, shows significant decrease in LH in women with OD due to O.C. as compared with fertile group.Conclusions: It was concluded that the decrease in serum ferritin levels in the blood may be associated directly or indirectly with subfertility caused by ovarian dysfunction