Author/Authors :
Zedan, H. University of Assiut - Faculty of Medicine - Department of Dermatology and Andrology, Egypt , Abd El-Baset, H.A. University of Assiut - Faculty of Medicine - Department of Clinical Pathology, Egypt , Abd-Elsayed, A.A. University of Assiut - Faculty of Medicine - Department of Public Health and Community Medicine, Egypt , El-Karn, M.F. University of Assiut - Faculty of Medicine - Department of Physiology, Egypt , Madkor, H.R.H. Al-Azhar University, Assiut Branch - Faculty of Pharmacy - Department of Biochemistry, Egypt
Abstract :
Allergic contact dermatitis to cement is a delayed-type hypersensitivity reaction in which cytokines interferon-gamma (IFN-γ) and vascular endothelial growth factor (VEGF) may be involved in persisting erythema and oedema. VEGF and IFN-γ levels in serum and skin lesions were measured in 32 Egyptian building workers with chronic allergic contact dermatitis due to occupational exposure to cement and 20 healthy controls. Dermatitis patients had significantly higher levels of serum and lesional skin VEGF and IFN-γ than controls. A significant positive correlation was found between tissue VEGF and the eczema area and severity index (EASI) score in dermatitis patients (r = 0.86). VEGF and IFN-γ may play a role in the pathogenesis of cement allergic contact dermatitis.
