Title of article :
Microwave promoted synthesis and antimicrobial activity of 3-thiazole substituted 2-styryl-4(3H)-quinazolinone derivatives
Author/Authors :
Jagani, Chandresh L. Affiliated to Sardar Patel University - V P R P T P Science College, India , Sojitra, Natvar A. Affiliated to Sardar Patel University - V P R P T P Science College, India , Vanparia, Satish F. Affiliated to Sardar Patel University - V P R P T P Science College, India , Patel, Tarosh S. Affiliated to Sardar Patel University - V P R P T P Science College, India , Dixit, Ritu B. Ashok Rita Patel Institute of Integrated Studies and Research in Biotechnology and Allied Sciences, India , Dixit, Bharat C. Affiliated to Sardar Patel University - V P R P T P Science College, India
Abstract :
The present paper describes an optimized reaction condition for the microwave promoted synthesis of newer 3-thiazole substituted 2-styryl-4(3H)-quinazolinone derivatives, which in turn were prepared in good yield by the treatment of various 2-styryl benzoxazinone derivatives with various 2-aminothiazoles using co-solvent under microwave irradiation. All the compounds were characterized by various spectroscopic techniques and analytical methods. All newly synthesized compounds have been screened for their in vitro antibacterial and antifungal activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus megaterium, Bacillus subtilis, and Aspergillus niger.
Keywords :
Microwave irradiation , 2 , Aminothiazoles , 2 , Styryl benzoxazinone , 2 , Styryl , 4(3H) , quinazolinones , Antimicrobial activity
Journal title :
Journal of Saudi Chemical Society
Journal title :
Journal of Saudi Chemical Society
