MONTELUKAST VERSUS NIGELLA SATIVA FOR MANAGEMENT OF SEASONAL ALLERGIC RHINITIS: A SINGLE BLIND COMPARATIVE CLINICAL TRIAL

Objective: To compare the therapeutic role of leukotriene receptor blocker Montelukast with N. Sativa seeds in seasonal allergic rhinitis patients. Methodology: Comparative uncontrolled single blind clinical assessment was carried out over forty seven untreated adult patients torment from seasonal allergic rhinitis and staring for outpatient management. All patients were chosen from different primary care health centers, registered and were divided in a single-blind approach to obtain Montelukast, 10 mg/day, group I (n=24) and 250 mg/day of N. Sativa, group II (n=23) orally for two weeks. Patients joined-up the study has completed the therapeutic plan. Results: Montelukast and N. Sativa both demonstrated a significant and early decrease in daytime as well as ophthalmic symptoms, while montelukast showed diminished and late effects on nighttime symptoms when compared with N. Sativa. In addition montelukast has also been showing to cause drug related side effects like headache, dizziness and heart burn. Conclusion: N. Sativa is safe and free from threat of serious adverse effects. So it is a reliable management alternative for seasonal allergic rhinitis patients.