Title of article :
Effect of zinc supplementation in children with asthma: a randomized, placebo-controlled trial in northern Islamic Republic of Iran
Author/Authors :
Ghaffari, J. mazandaran university of medical sciences - Antimicrobial Resistant Nosocomial Infection Research Center - Department of Paediatrics, ايران , Khalilian, A. mazandaran university of medical sciences - Department of Statistics, ايران , Salehifar, E. mazandaran university of medical sciences - Department of Pharmacology, ايران , Khorasani, E. mazandaran university of medical sciences - Antimicrobial Resistant Nosocomial Infection Research Center - Department of Paediatrics, ايران , Rezaii, M.S. mazandaran university of medical sciences - Antimicrobial Resistant Nosocomial Infection Research Center - Department of Paediatrics, ايران
Abstract :
There are conflicting reports about the benefits of zinc supplements in childhood asthma. This study examined the effect of zinc supplementation in children with asthma attending an outpatient clinic in Sari, Islamic Republic of Iran. In a randomized, double-blind, placebo-controlled clinical trial over 8 weeks, 284 children on inhaled steroids were allocated to receive zinc supplements (50 mg/day) (n = 144) or placebo (n = 140). Cases and controls had low initial serum zinc concentrations [61.8 (SD 7.3) μg/dL and 60.9 (SD 4.3) μg/dL]. After treatment, mean serum zinc level in the case group was significantly higher [129 (SD 20.4) μg/dL] than in the controls [63 (SD 8.6) μg/dL]. There were no significant differences in IgE levels before and after treatment. The case group showed significant improvements in clinical symptoms such as cough, wheezing and dyspnoea and in all spirometry parameters (FVC, FEV1 and FEV1/FVC).
Journal title :
Eastern Mediterranean Health Journal
Journal title :
Eastern Mediterranean Health Journal
