SYNTHESIS OF SOME NEW DERIVATIVES OF 1,2,4-TRIAZOLES AND THIAZOLE FROM 1,2,3,4-TETRAHYDROCARBAZOL AND STUDY THEIR BIOLOGICAL ACTIVITY

New heterocyclic derivative of 1,2,3,4-tetrahydrocarbazol (THCz) comprising Thiazole and 1,2,4-triazole moieties are reported reaction 1,2,3,4-tetrahydrocarbazol (THCz) [1] with ethyl chloroacetate and potassium hydroxide by fusion method resulted in 1-(ethylacetate)-1,2,3,4- tetrahydro-9H-carbazole [2], Then conversion these ester to [semucarbazide, phenylsemicarbazide, thiosemicarbazide, urea and thiourea] derivatives through its reaction with [semicarbazide, phenylsemicarbazide, thiosemicarbazide, urea and thiourea] respectively [3, 4, 5, 9 and 10]. Furthermore substituted triazole were prepared through the cyclization compounds [3,4 and 5] in alkaline media (4N. NaOH) to give compounds [6,7 and 8] respectively. While cyclization compounds [9, 10] by used p-Bromophencyl bromide gave oxazole [11] and thiazole [12], furthermore the compound [2] was treated with hydrazine hydrate gave the corresponding hydrazine derivative [13] which the conversion for dithiocarbazate salt [14] which was then cyclized with hydrazine hydrate to give substituted triazole [15]. The prepared compounds identified by spectral methods [FTIR, 1H-NMR, 13C-NMR] and measurement some of its physical properties and some specific reaction, furthermore we were studied the effects of the preparing compounds on some strains of bacteria, Staphylococcus aureus, Staphylococcus epideruidis, Pseudomonas aeruginosa, Escherichia coli and one yeast (Candidau).