The Histological Changes of Albino Mice Embryos Kidneys after Exposure In Utero to Topiramate

Background: The kidneys can be damaged by a large number of therapeutic agents. Mechanisms of injury are varied and all renal structures may be affected. Objectives: To discuss the effect of topiramate (one of the new antiepileptic drugs) on renal histologyby studying the pathological features of the kidneys of embryos of albino mice, Balbls species (Swissorigin, Mus musculus) after intrauterine exposure to that drug and to determine the frequencies of thesepathological findings. Setting: Laboratory of Postgraduate Studies at the Department of Anatomy, Histology and Embryologyin Mosul College of Medicine, Mosul University, Mosul, Northern Iraq. Methods: This study was conducted over a period of 2 months extending from July 1, 2010 toSeptember 1, 2010. Male and female albino mice, Balbls species (Swiss origin, Mus musculus) werechosen from 10-12 weeks of age, their mean weight was about 28±2 gms and they were healthy. Theseanimals were put in good environmental conditions and underwent acclimatization in a 12 hour light-dark cycle. The animals were put in plastic cages with food and water ad libitum.