Author/Authors :
WAQAR, MUHAMMAD ANWAR University of Karachi - International Center for Chemical and Biological Sciences - Dr Panjwani Center for Molecular Medicine and Drug Research, Pakistan , SHAUKAT, SOHAIL University of Karachi - International Center for Chemical and Biological Sciences - Dr Panjwani Center for Molecular Medicine and Drug Research, Pakistan , NOORI, MOHAMMAD YAHYA University of Karachi - International Center for Chemical and Biological Sciences - Dr Panjwani Center for Molecular Medicine and Drug Research, Pakistan , WAQAR, MUHAMMAD ATIF Washington University - School of Medicine - Division of Medical Oncology, USA
Abstract :
RNA interference is the sequence specific gene silencing technique which holds promises and a lot of potential to become the drug of choice for many unresolved diseases. During the past few years, important studies have been done in translating the potential of RNAi into therapies for human disease. Viral infections, cancer, neurodegradative diseases and dominantly inherited genetic disorders are top most among the list of those diseases, which have the greatest potential to be treated by RNAi techniques. The rational design of RNAi based drugs can improve the therapeutic properties based on the recent progress in understanding the mechanism of action. The introduction of chemical modifications into siRNA and the improved delivery strategies that associate with high specificity and efficiency are being discussed intensively.
