Title of article
Synthesis and Antimicrobial Evaluation of 6-Chloroquinolinylhydrazones and Acyclonucleosides of 7-Chloro-1,2,4-Triazolo[4,3-a]quinolines
Author/Authors
HASANEN, IJEHAN ABD EL RAZEK Suez Canal University - Faculty of Science - Chemistry Department, Egypt , IBRAHIM, EL SAYED ISMAIL Suez Canal University - Faculty of Science - Chemistry Department, Egypt , ZEIN, MOHAMED ABD EL-LATIF Suez Canal University - Faculty of Science - Chemistry Department, Egypt , REZKI, NADJET Alexandria University - Faculty of Science - Chemistry Department, Egypt , EL-ASHRY, EL SAYED HELMY Alexandria University - Faculty of Science - Chemistry Department, Egypt , EL-ASHRY, EL SAYED HELMY University of Karachi - H E J Research Institute - International centre for Chemical Sciences, Pakistan
From page
276
To page
284
Abstract
Condensation of 6-chloro-2-hydrazinoquinoline (1) with monosaccharides 2a-e gave the corresponding sugar hydrazones 3a-e which upon acetylation gave the corresponding acetates 4f-j. Cyclization of 3a-e using iron (III) chloride afforded the acyclic nucleosides of triazoloquinolines Sa-e which were also acetylated to give 6f-j. Compound 1 was also condensed with aldehydes and isatin to give the corresponding hydrazones 7-10. Reactions of 1 with etbylchloroformate. phthalic anhydride. acetyl acetone and tosyl chloride were also investigated. All compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria.
Journal title
Journal of the Chemical Society of Pakistan
Journal title
Journal of the Chemical Society of Pakistan
Record number
2645648
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