Title of article :
Synthesis and Antimicrobial Evaluation of 6-Chloroquinolinylhydrazones and Acyclonucleosides of 7-Chloro-1,2,4-Triazolo[4,3-a]quinolines
Author/Authors :
HASANEN, IJEHAN ABD EL RAZEK Suez Canal University - Faculty of Science - Chemistry Department, Egypt , IBRAHIM, EL SAYED ISMAIL Suez Canal University - Faculty of Science - Chemistry Department, Egypt , ZEIN, MOHAMED ABD EL-LATIF Suez Canal University - Faculty of Science - Chemistry Department, Egypt , REZKI, NADJET Alexandria University - Faculty of Science - Chemistry Department, Egypt , EL-ASHRY, EL SAYED HELMY Alexandria University - Faculty of Science - Chemistry Department, Egypt , EL-ASHRY, EL SAYED HELMY University of Karachi - H E J Research Institute - International centre for Chemical Sciences, Pakistan
Abstract :
Condensation of 6-chloro-2-hydrazinoquinoline (1) with monosaccharides 2a-e gave the corresponding sugar hydrazones 3a-e which upon acetylation gave the corresponding acetates 4f-j. Cyclization of 3a-e using iron (III) chloride afforded the acyclic nucleosides of triazoloquinolines Sa-e which were also acetylated to give 6f-j. Compound 1 was also condensed with aldehydes and isatin to give the corresponding hydrazones 7-10. Reactions of 1 with etbylchloroformate. phthalic anhydride. acetyl acetone and tosyl chloride were also investigated. All compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria.
