Author/Authors :
AHMED, EJAZ University of the Punjab - Institute of Chemistry, Pakistan , ABDUL MALIK University of Karachi - Intemational Center for Chemical Sciences - H E J Research Institute of Chemistry, Pakistan , ALI MUNAWAR, MUNAWAR University of the Punjab - Institute of Chemistry, Pakistan , AHMAD NAGRA, SAEED University of the Punjab - Institute of Chemistry, Pakistan , AHMED, MUHAMMAD MUBEEN PCSIR Laboratories Complex - Pharmaceutical Research Centre, Pakistan , ANWAR, JAMIL University of the Punjab - Institute of Chemistry, Pakistan , AFTAB QAZI, MUHAMMAD PCSIR Laboratories Complex - Pharmaceutical Research Center, Pakistan , SHARIF, AHSAN University of the Punjab - Institute of Chemistry, Pakistan , AFZA, NIGHAT PCSIR Labs. - Pharmaceutical Research Centre, Pakistan , ASHRAF, MUHAMMAD Islamia University Bahawalpur - Department of Pharmacy, Pakistan
Abstract :
From the whole plant of Silybum marianum Gaerth five terpenoids, four steroids and four flavonoids were isolated. The structure of these com-pounds were established by spectroscopic (UV, IR, 1D-NMR, and FAB-MS) methods. All of them have been isolated for the first time from the genus Silybum. Compounds 1-9 showed moderate to potent antifungal activity while the flavonoids (10-13) showed free radical scavenging activity which was deter-mined using the radical 2,2-diphenyl-1-picrydrazyl (DPPH), spectroscopically.
