Title of article
Synthesis, Characterization and Cytotoxic Activity of Some Pyrimidine Derivatives
Author/Authors
Ahmed, Salman Ali Al-Nahrain University - College of Science - Department of Chemistry, Iraq , Naji, Tamara Sami Al-Nahrain University - College of Science - Department of Chemistry, Iraq , Mohammad, Farooq Ibrahem Al- Nahrain University - Biotechnology Research Center, Iraq
From page
84
To page
92
Abstract
Synthesis of some pyrimidine derivatives which plays an important role in the medicinal chemistry because it possesses promising cytotoxic activity. The synthesized compounds were characterized by UV-Visible and FT-IR spectral data. Some of the new compounds were evaluated for their potential cytotoxicity against two different human cancer cell lines HepG2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) in vitro, using Neutral Red and MTT assays. The synthesized compounds were active against two cell lines under study and a toxic effect was clear with a significant difference at the level of probability (p 0.0001) and this effect was contrasted among different concentrations for each synthesized compound.
Keywords
Pyrimidine derivatives , Cytotoxic activity , Human cancer cell lines
Journal title
Al-Nahrain Journal Of Science
Journal title
Al-Nahrain Journal Of Science
Record number
2646138
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