Title of article :
Synthesis, Characterization and Cytotoxic Activity of Some Pyrimidine Derivatives
Author/Authors :
Ahmed, Salman Ali Al-Nahrain University - College of Science - Department of Chemistry, Iraq , Naji, Tamara Sami Al-Nahrain University - College of Science - Department of Chemistry, Iraq , Mohammad, Farooq Ibrahem Al- Nahrain University - Biotechnology Research Center, Iraq
Abstract :
Synthesis of some pyrimidine derivatives which plays an important role in the medicinal chemistry because it possesses promising cytotoxic activity. The synthesized compounds were characterized by UV-Visible and FT-IR spectral data. Some of the new compounds were evaluated for their potential cytotoxicity against two different human cancer cell lines HepG2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) in vitro, using Neutral Red and MTT assays. The synthesized compounds were active against two cell lines under study and a toxic effect was clear with a significant difference at the level of probability (p 0.0001) and this effect was contrasted among different concentrations for each synthesized compound.
Keywords :
Pyrimidine derivatives , Cytotoxic activity , Human cancer cell lines
Journal title :
Al-Nahrain Journal Of Science
Journal title :
Al-Nahrain Journal Of Science
