Author/Authors :
MUSHTAQ, NOUSHEEN University of Karachi - Department of Pharmaceutical Chemistry, Pakistan , SAIFY, Z.S. University of Karachi - HEJ Research Institute of Chemistry - Department of Pharmaceutical Chemistry, Pakistan , NOOR, FOZIA Saarland University - Biochemical Engineering, Germany , TAKWEEN, SHAMOONA University of Karachi - Faculty of Pharmacy - Department of Pharmacology, Pakistan , AKHTAR, SHAMIM University of Karachi - Department of Pharmaceutical Chemistry, Pakistan , ARIF, MUHAMMAD University of Karachi - Department of Pharmaceutical Chemistry, Pakistan , KHAN, KHALID M. University of Karachi - HEJ Research Institute of Chemistry - Department of Pharmaceutical Chemistry, Pakistan
Abstract :
As a part of our program to discover novel analogues of 7-azaindole (1H-Pyrrolo[2,3-b] pyridine) having useful biological activities, some derivatives have been synthesized and evaluated for their analgesic and hypotensive activity. Compounds evaluated by thermal stimuli (tail immersion method) at the dose of 50 mg/kg of body weight revealed significant analgesic activity. Pethidine was used as reference drug. Same compounds tested at the dose of 75mg/kg of body weight showed toxicity. Compounds tested for their effect on blood pressure in normotensive rat produced slight fall in blood pressure.
Keywords :
7 , azaindole , analgesic , hypotensive activity , synthesis
