Author/Authors :
DAS, BIPLAB K. East West University - Department of Pharmacy, Bangladesh , BEPARY, SUKUMAR East West University - Department of Pharmacy, Bangladesh , DATTA, BIDYUT K. University of Dhaka - Department of Pharmaceutical Technology, Bangladesh , CHOWDHURY, A. K. AZAD University of Dhaka - Department of Clinical Pharmacy and Pharmacology, Bangladesh , ALI, MOHAMMAD SHAWKAT University of Dhaka - Department of Clinical Pharmacy and Pharmacology, Bangladesh , ROUF, ABU SHARA SHAMSUR University of Dhaka - Department of Pharmaceutical Technology, Bangladesh
Abstract :
Two partially purified organic fractions designated by PR1 and PR2 of the fat free ethanol (95%) extract of aerial parts of Phyllanthus reticulatus were tested for the hepatoprotective activity in rats against CCl4-induced liver damage. The rats receiving the fractions showed promising hepatoprotective activity as evident from significant changes of pentobarbital-induced sleeping time, changes in serum levels of sGPT, sGOT, sALP and bilirubin and also from histopathological changes as compared to CCl4-intoxicated rats.
Keywords :
Phyllanthus reticulatus , organic fractions , hepatoprotective activity , CCl4 , induced liver damage
