Author/Authors :
SUBRAMANIAN, S PSG College of Pharmacy - Department of Pharmaceutics, India , SANKAR, V PSG College of Pharmacy - Department of Pharmaceutics, India , MANAKADAN, ASHA ASOKAN Grace College of Pharmacy - Department of Pharmaceutics, India , ISMAIL, SAREENA Grace College of Pharmacy - Department of Pharmaceutics, India , ANDHUVAN, G Karpagam Pharmacy College - Department of Pharmacy Practice, India
Abstract :
Cetirizine orodispersible tablets were prepared to achieve quick onset of action and for maximum bioavailability. Tablets were prepared using cetirizine along with camphor and mannitol in the proportion of 1:1:1, 1:1:3, and 1:1:6. The flow property of granules was found to be good for the formulation CZ2 (1:1:3). The hardness and friability of all the formulations were found to be within the standard limit for orodispersible tablets. Disintegration time was found to be rapid in formulation CZ2 (1:1:3).The in vitro dissolution time was found to be 100% in 11 minutes for the formulation CZ2 (1:1:3).
Keywords :
Cetirizine orodispersible tablets , HPLC method , hausner ratio , wetting time
