Title of article :
TREATMENT OF NIGELLA SATIVA IN EXPERIMENTAL SEPSIS MODEL IN RATS
Author/Authors :
ALICI, OZLEM Medical Park Hospital - Department of Infectious Diseases and Clinical Bacteriology, Turkey , KAVAKLI, HAVVA SAHIN Ankara Ataturk Training and Research Hospital - Department of Emergency Medicine, Turkey , KOCA, CEMILE Fatih University - Faculty of Medicine - Department of Biochemistry, TURKEY , ALTINTAS, NERIMAN DEFNE Ankara Ataturk Training and Research Hospital - Department of Medical Intensive Care, Turkey
Abstract :
This experimental study was designed to determine effects of Nigella sativa oil (NSO) on endothelin-1 (ET-1) level and oxidative stress parameters, superoxide dismutase (SOD) and malondialdehyde (MDA) in a rat sepsis model. Twenty four adult Wistar albino rats were divided randomly into three groups: sham group (group 1), sepsis group (group 2), sepsis group pretreated with NSO (group 3). Serum ET-1, tissue SOD and tissue MDA levels were measured in all groups. Compared to group 1, ET-1 and MDA levels were higher in group 2. ET-1 and MDA levels in NSO pretreated group 3 were lower with respect to group 2 (p 0.03, and p 0.02, respectively). Additionally, SOD levels in group 3 were found to be higher than group 2 (p 0.02). Based on our results, it can be concluded that NSO may have a positive impact on ET-1 levels and oxidative stress induced by sepsis in experimental rat models.
Keywords :
Sepsis , Nigella sativa oil , endothelin , superoxide dismutase , malondialdehyde.
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
