Author/Authors :
ALAM, NAUSHEEN University of Karachi - Faculty of Pharmacy - Department of Pharmacology, Pakistan , HALEEM, DARAKSHAN JABEEN University of Karachi - Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Unit, Pakistan , NAJAM, RAHILA University of Karachi - Faculty of Pharmacy - Department of Pharmacology, Pakistan , HAIDER, SYEDA University of Karachi - Department of Biochemistry, Neurochemistry and Biochemical Neuropharmacology Research Unit, Pakistan , AHMED, SHAHIDA PERVEEN University of Karachi - Faculty of Pharmacy - Department of Pharmacology, Pakistan
Abstract :
Long term intake of coffee is known to produce anxiety and suppression of appetite. 5-hydroxytryptamine (5-HT) acting via 5-HT-2C receptors elicits anorexia and anxiety. The present study is design to monitor metachloro phenyl piperazine (m-CPP) at a dose of 3mg/ml/kg, induces hypophagia and hypolocomotion in rats taking a solution of caffeine (a component of coffee and tea) or theophylline (a component of tea) as a sole source of water. We found that hypophagic and hypolocomotive effects of m-CPP were attenuated in theophylline but not in caffeine treated animals suggesting that long term intake of theophylline may attenuate anorexiogenic and anxiogenic effects of 5-HT. A possible role of 5-HT-2C receptors in the modulation of anxiety and appetite in people drinking coffee or tea discussed.
Keywords :
Anxiety , anorexia , m , CPP , caffeine , theophylline.
