Title of article
CYTOTOXICITY OF ISOLATED COMPOUNDS FROM THE EXTRACTS OF STRUCHIUM SPARGANOPHORA (LINN) KTZE ASTERACEAE
Author/Authors
KASIM, LATEEF SAKA Olabisi Onabanjo University - Faculty of Pharmacy, Nigeria , FERRO, VALERIE University of Strathclyde - Department of Immunology, UK , ODUKOYA, OLUWAKEMI A University of Lagos - Faculty of Pharmacy, Nigeria , UKPO, GRACE EIGBIBHALU University of Lagos - Faculty of Pharmacy, Nigeria , SEIDEL, VERONIQUE University of Strathclyde - Department of Pharmaceutical Sciences, UK , GRAY, ALEXANDER I University of Strathclyde - Department of Pharmaceutical Sciences, UK , WAIGH, ROGER University of Strathclyde - Department of Pharmaceutical Sciences, UK
From page
475
To page
478
Abstract
Chemical investigation of the leaves of Struchium sparganophora by the application of VLC, CL and PTLC resulted in isolation of three compounds. The cytotoxicity activity of these compounds on malignant human cultured cells was examined. Vernodalin showed a significant cytotoxic activity on the melanoma and ovarian cancer cell lines (P 0.05) while the conjugated 3 methyl, 2, 6 hexacosedienol and luteolin caused cell death after 48h reculture without them. These compounds portend an effective remedy if subjected to structural modification to enhance its’ efficacy and the dietary importance of this plant as a culinary herb in west Africa countries is evidence by the presence of these antitumour compounds in this plant.
Keywords
Struchium sparganophora , cytotoxicity , luteolin , vernodalin , 3 methyl , 2 , 6 hexacosedienol.
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Record number
2647484
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