Author/Authors :
Aziz-ur-Rehman Government College University - Department of Chemistry, Pakistan , Afroz, Sumbel Government College University - Department of Chemistry, Pakistan , Abbasi, Muhammad Athar Government College University - Department of Chemistry, Pakistan , Tanveer, Wajeeha Government College University - Department of Chemistry, Pakistan , Khan, Khalid Mohammed University of Karachi - HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, Pakistan , Ashraf, Muhammad Islamia University of Bahawalpur - Department of Biochemistry and Biotechnology, Pakistan , Ahmad, Irshad Islamia University of Bahawalpur - Department of Pharmacy, Pakistan , Afzal, Iftikhar Islamia University of Bahawalpur - Department of Pharmacy, Pakistan , Ambreen, Nida University of Karachi - HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, Pakistan
Abstract :
In the present study, a series of N-substituted derivatives of 2-phenylethylamine has been synthesized. The reaction of 2-phenylethylamine (1) with benzene sulfonyl chloride (2) yielded N-(2-phenylethyl) benzenesulfonamide (3), which further on treatment with alkyl/acyl halides (4a-i) in the presence of sodium hydride furnished into Nsubstituted sulfonamides (5a-i). These derivatives were characterized by IR, 1H-NMR and EI-MS and then screened against acetyl cholinesterase (AChE), butyryl cholinesterase (BChE) and lipoxygenase enzyme (LOX) and were found to be potent inhibitors of butyryl cholinesterase only.
Keywords :
2 , phenylethylamine , sulfonamides , butyryl cholinesterase , 1H , NMR and EI , MS.
