Title of article :
Evaluation of biological activities of Alpinia mutica Roxb. and its chemical constituents
Author/Authors :
Mustahil, Noorul Adawiyah Universiti Putra Malaysia - Faculty of Science - Department of Chemistry, Malaysia , Sukari, Mohd Aspollah Universiti Putra Malaysia - Faculty of Sciences - Department of Chemistry, Malaysia , Abdul, Ahmad Bustamam UPM Serdang - Institute of Bioscience - UPM-MAKNA Cancer Research Laboratory, Malaysia , Ali, Nor Azah Forest Research Institute Malaysia (FRIM), Malaysia , Lian, Gwendoline Ee Cheng Universiti Putra Malaysia - Faculty of Science - Department of Chemistry, Malaysia
Abstract :
Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5,6- dehydrokawain (1), flavokawin B (2), pinostrobin (3) and pinocembrin (4) together with β-sitosterol (5). All crude extracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50 values less than 19 μg/mL, while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86±0.37 μg/mL. Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl (DPPH) radical scavenging activity tests.
Keywords :
Phytochemicals investigation on rhizomes of Alpinia mutica has afforded five compounds namely 5 , 6 , dehydrokawain (1) , flavokawin B (2) , pinostrobin (3) and pinocembrin (4) together with β , sitosterol (5). All crudeextracts of the plant demonstrated strong cytotoxicity against CEMss (human T4 lymphoblastoid) cancer cells with IC50values less than 19 μg , mL , while flavokawin B (2) was the most cytotoxic isolate with IC50 value 1.86±0.37 μg , mL.Most of the crude extracts and isolated compounds showed weak activity in antimicrobial and diphenylpicrylhydrazyl (DPPH) radical scavenging activity tests.
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
