Author/Authors :
Jahan, Sarwat Federal Urdu University of Arts, Science and Technology - Gulshan-e-Iqbal Campus, Pakistan , Akhtar, Shamim University of Karachi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Pakistan , Saify, Zafar Saied University of Karachi - HEJ Research Institute of Chemistry, Pakistan , Mushtaq, Nousheen University of Karachi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Pakistan , Sial, Ali Akbar Federal Urdu University of Arts, Science and Technology - Gulshan-e-Iqbal Campus, Pakistan , Kamil, Arfa Federal Urdu University of Arts, Science and Technology - Gulshan-e-Iqbal Campus, Pakistan , Arif, Muhammed University of Karachi - Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Pakistan
Abstract :
Synthesis of novel phenacyl derivatives of alkyl piperidine as cytotoxic agents via simple and single step reaction procedure is going to be reported here. Twelve new compounds were successfully synthesized in moderate yield and in solid form. Their synthesis was confirmed by TLC, melting point, CHN analysis and through different spectral studies such as UV, IR, Mass and proton NMR. The advantages of this synthetic route are simple operation, mild reaction conditions and good yields. These newly synthesized derivatives were extensively explored for their cytotoxicity by brine shrimp lethality assay.
