Title of article :
3-[(2-chloroquinolin-3-yl)methyl]quinazolin-4(3H)-ones as potential larvicidal agents
Author/Authors :
Roopan, Selvaraj Mohana VIT University - School of Advanced Sciences - Organic Medicinal Chemistry Research Laboratory, Organic Chemistry Division, India , Khan, Fazlur-Rahman Nawaz VIT University - School of Advanced Sciences - Organic Medicinal Chemistry Research Laboratory, Organic Chemistry Division, India , Khan, Fazlur-Rahman Nawaz Korea Basic Science Institute - Busan center, South Korea , Jin, Jong Sung Korea Basic Science Institute - Busan center, South Korea
Abstract :
The larvicidal effect of series of 3-[(2-chloroquinolin-3-yl)methyl]quinazolin-4(3H)-ones, 5a-e, against Chironomus tentans Fabricius has been investigated. The results showed that tested compounds demonstrated strong larvicidal activity, and caused high percentage of mortality after 24 h at the doses of 40-100 μg/ml, especially in the case of 3-[(2-chloro-8-methyquinolin-3-yl)methyl]quinazolin-4(3H)-one, 5b, that act as a promising larvicidal agent.
Keywords :
Larvicidal activity , 3 , [(2 , chloroquinolin , 3 , yl)methyl]quinoline , 4(3H) , ones , synthesis
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
Journal title :
Pakistan Journal Of Pharmaceutical Sciences
