Title of article
Antioxidant activities in vitro and in vivo of water-soluble polysaccharide isolated from Sparganium stoloniferum Buch.-Ham
Author/Authors
Wang, Xinsheng Nanjing University of Chinese Medicine - Pharmaceutical School, China , Wang, Xinsheng Henan University of Science and Technology - Chemical Engineering and Pharmaceutical School, China , Wu, Yanfang Xinxiang Medical University - Pharmaceutical School, China , Wu, Qinan Nanjing University of Chinese Medicine - Pharmaceutical School, China , Yue, Wei Nanjing University of Chinese Medicine - Pharmaceutical School, China , Liang, Qiaoli Nanjing University of Chinese Medicine - Pharmaceutical School, China
From page
147
To page
151
Abstract
In this study, the crude polysaccharides from Sparganium stoloniferum Buch.-Ham were prepared using hotwater extraction and further deproteinzated by Sevage method. The purified fraction of crude polysaccharide was obtained using a DEAE-52 cellulose chromatography and named with WSSP. Then, the antioxidant capacities of WSSP were assessed in vitro and in vivo. The results in vitro indicated that the WSSP possessed notably free radical scavenging capacity. And the antioxidant abilities were dose-dependent and increased with increasing dose of sample. The findings in vivo showed the gavage administration of WSSP can increase SOD and TAOC activities, and decrease MDA levels in tissue and serum of mice. Therefore, the WSSP may serve as a potential antioxidant.
Keywords
Polysaccharide , Antioxidant activity , Sparganium stoloniferum Buch. , Ham , In vitro and in vivo
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Journal title
Pakistan Journal Of Pharmaceutical Sciences
Record number
2648164
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