Title of article :
Rifampicin-resistant tuberculosis in Iran: A systematic review and meta-analysis
Author/Authors :
Bahraminia ، Farhad Applied Microbiology research center, Systems Biology and Poisonings Institute - Baqiyatallah University of Medical Sciences , Azimi ، Taher Department of Pathobiology - School of Public Health - Tehran University of Medical Sciences , Zangiabadian ، Moein Student Research Committee, School of Medicine - Shahid Beheshti University of Medical Sciences , Nasiri ، Mohammad Javad Department of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences , Goudarzi ، Mehdi Department of Microbiology - School of Medicine - Shahid Beheshti University of Medical Sciences , Dadashi ، Masoud Department of Microbiology - School of Medicine - Alborz University of Medical Sciences , Imani Fooladi ، Abbas Ali Applied Microbiology research center, Systems Biology and Poisonings Institute - Baqiyatallah University of Medical Sciences
Abstract :
Rifampicin (RIF)resistant strain of Mycobacterium tuberculosis is an important barrier to effective tuberculosis (TB) treatment and prevention. The present study aimed to determine the frequency of RIFresistant TB among patients with confirmed TB. Pubmed/Medline, Embase, Web of Science, and Scopus were searched for relevant articles published between January 1980 and January 2020. We pooled data with random-effects models when appropriate. After screening 1608 citations, 30 studies covering 8215 patients with TB were included. The pooled frequency of RIF-resistance among all patients with TB was 8.0% (95% CI 4.0–12.0). Our subgroup analysis showed that 4.0% of newly diagnosed cases and 36.0% of previously-treated TB patients from different settings in Iran were RIFresistant. Our study showed that the frequency of RIFresistance among patients with TB was 8.0%. Programmatic implementation of rapid drug susceptibility testing (DST) such as the Xpert MTB/RIF assay as a primary diagnostic test for persons suspected of having a RIFresistant TB would be helpful for the control of the drug resistance.
Keywords :
Drug resistance , Iran , rifampicin , Tuberculosis , Xpert MTB , RIF assay
Journal title :
Iranian Journal of Basic Medical Sciences
Journal title :
Iranian Journal of Basic Medical Sciences
