Title of article :
Is there any association of extra hepatic biliary atresia with cytomegalovirus or other infections?
Author/Authors :
Soomro, Ghous Bukhsh Sindh Institute of Urology and Transplantation - Department of Hepatogastroenterology, Pakistan , Abbas, Zaigham Sindh Institute of Urology and Transplantation - Department of Hepatogastroenterology, Pakistan , Hassan, Mujahid Sindh Institute of Urology and Transplantation - Department of Hepatogastroenterology, Pakistan , Luck, Nasir Sindh Institute of Urology and Transplantation - Department of Hepatogastroenterology, Pakistan , Memon, Yousuf Sindh Institute of Urology and Transplantation - Department of Hepatogastroenterology, Pakistan , Khan, Abdaal Wasim Sindh Institute of Urology and Transplantation - Department of Hepatogastroenterology, Pakistan
Abstract :
The objective of this study was to find any association of extrahepatic biliary atresia (EHBA) with a possible infectious etiology. Infants diagnosed to have EHBA were tested by blood PCR for cytomegalovirus (CMV ), Ebstein-Barr virus, HBsAg, anti-HCV and IgM antibodies for CMV, toxoplasma, rubella, and herpes infections. Thirty-three infants of EHBA were included in the study, male 22, median age when diagnosed 2.5 months (range 1.0-5.0 months). On examination pallor, oedema and hepatosplenomegaly were seen in all and ascites and microcephaly in 19 (57.6%).Centile height and weight were 50th in 23 and 25th in 10.Persistent CMV infection documented by PCR was present in 14 (42%) patients. Eleven of these also had positive CMV IgM antibodies. No other above mentioned infections could be detected in our patients of EHBA. Our data suggests that CMV infection may play a role in the pathogenesis and progression of EHBA.
Keywords :
Extrahepatic biliary atresia , Cytomegatovirus , PCR
Journal title :
Journal of the Pakistan Medical Association (Centre) JPMA
Journal title :
Journal of the Pakistan Medical Association (Centre) JPMA