Author/Authors :
Mahmoodi Nesheli, Hassan babol university of medical sciences - Department of Pediatric Hematology Oncology, ايران , Galini Moghaddam, Tahereb mazandaran university of medical sciences - Department of Obstetric and Gynecology, ايران , Tamaddoni, Ahmad babol university of medical sciences - Department of Pediatric Hematology Oncology, ايران , Darzi, Ali Asghar babol university of medical sciences - Department of Surgery, ايران , Esmaeili Dooki, Mohammad Reza babol university of medical sciences - Department of Pediatric Gastroenterology, ايران , Bijani, Ali babol university of medical sciences, ايران , Mahmoodi Nesheli, Mohsen babol university of medical sciences, ايران
Abstract :
Objective: To evaluate the correlation of portal vein thrombosis and splenectomy in β-thalassemia major patients visiting Babol Medical University, Iran. Methods: This cohort study was done from 1997 to 2008. In our study, major β-thalassemic patients visiting for transfusion at least once a month at Amirkola Children s Hospital were selected. Portal vein thrombosis was diagnosed through Doppler ultrasound in symptomatic patients. Cases were 160 β-thalassemia major patients who underwent splenectomy and 160 remaining thalassemic patients without splenectomy were controls. Statistical comparison with Fisher exact test was performed. Results: Five cases had suffered from portal vein thrombosis (P=0.03). Majority patients with portal vein thrombosis had their symptoms after first month of the operation. Conclusion: Correlation of splenectomy with portal vein thrombosis is statistically significant among β- thalassemic children from Iran.
Keywords :
Splenectomy , Portal vein thrombosis , β , thalassemia major
