Title of article :
Massive splenomegaly in acute erythroid leukaemia (FAB Class-M6): An unusual Presentation
Author/Authors :
Sherazi, Syed Furqan Haider , Butt, Zeeshan
From page :
989
To page :
990
Abstract :
AML-M6 has a peak incidence in the seventh decade with slight male preponderance, and can also present at a younger age. The usual features are anaemia, thrombocytopenia, malaise, fatigue, easy bruising, epistaxis and petechiae. Splenomegaly may occur in 20-40 % of the cases but massive splenomegaly is rare presentation and have been only reported once in humans and once in animals. A 22 year Asian female, presented with fatigue, pallor, mild jaundice, exertional dyspnoea ,epigastric pain, tender right hypochondrium and massive splenomegaly. Investigations revealed anaemia and thrombocytopenia, tear drop cells, basophilic stippling, piokilocytosis and anisochromia; increased uric acid and LDH. Abdominal ultrasound showed enlarged liver (22cm) and spleen (20cm). Bone marrow aspiration revealed 51% erythroid and 24% non-erythroid precursors, depressed leukopoeisis and megakarypoeisis. Erythroblasts were PAS and CD71 positive and also reacted to Antihaemoglobin-Antibody. This report highlights characteristic features and diagnostic criteria of erythroleukaemia, differential diagnosis of massive splenomegaly and their rare association.
Keywords :
AML M , 6 , Massive Splenomegaly , Erythroleukaemia , Hepatomegaly.
Journal title :
Journal of the Pakistan Medical Association (Centre) JPMA
Journal title :
Journal of the Pakistan Medical Association (Centre) JPMA
Record number :
2652108
Link To Document :
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