Cardiopulmonary effects of Detomidine-Propofol and Ketamine administration in the Donkeys

The effects of detomidine-propofol and ketamine on the heart rate, respiratory rate, blood gases and temperature were investigated in six healthy donkeys weighting from(100-150kg). The animals received premedication with detomidine HCL (10 μg/kg bwtiv) followed after 5 min with a single intravenous (i.v.) bolus dose of propofol (1mg/kg/bwt iv) and approximately 2 to 3 min by a single i.v. bolus dose of ketamine HCL (2.2 mg/kg bwt iv). All parameters were evaluated before the administration of detomidine and at 5,10, 15,20,25and 30 min after administration of detomidine and anesthetics.The heart rate decreased significantly after administration of the anesthetic drugs(propofol and ketamine). The mean respiratory rate decreased significantly after administration of the detomidine and anesthetic drugs (propofol and ketamine). PaO2 was littleeffect. The body temperature slightly decreased at all points in time. The data showed that the combination of detomidine-ketamine,propofol caused an inhibition of the cardiovascular system. This combination is responsible for little distributed ventilation, very small effect PaO2 and a declined in body temperature in the anaesthesia period in donkeys.