Author/Authors :
Shaikh, Quratulain Aga Khan University Hospital - Fogarty International Center, National Institute of Neurologic Disorders and Stroke - Stroke Service and Vascular Fellowship Program, International Cerebrovascular Translational Clinical Research Training Program, Pakistan , Kamal, Ayeesha Kamran Aga Khan University Hospital - Fogarty International Center, National Institute of Neurologic Disorders and Stroke - Stroke Service and Vascular Fellowship Program, International Cerebrovascular Translational Clinical Research Training Program, Pakistan
Abstract :
Early mortality after ischaemic stroke is attributed largely to stroke associated pneumonia and is reported to be somewhere between 7-22%. Although some patients are at a higher risk of pneumonia following stroke including those within the acute phase (9-36 hours.) and those with nonlacunar stroke in the MCA territory. There is yet no evidence on the outcome of acute stroke if prophylactic antibiotic therapy is given to prevent aspiration pneumonia in high risk patients although some animal studies have suggested benefits of the same. The Preventive Antibacterial Therapy in Acute Ischaemic Stroke (PANTHERIS) trial was done between May 2003 and July 2006 to observe the difference in outcome of acute stroke if prophylactic antibiotic therapy was given.
