Author/Authors :
Geramizadeh, Bita shiraz university of medical sciences - Shiraz Medical School, Transplant Research Center - Department of Pathology, ايران , Nikeghbalian, Saman shiraz university of medical sciences - Shiraz Medical School, Transplant Research Center - Department of Pathology, Department of Surgery, ايران , Shamsaifar, Alireza shiraz university of medical sciences - Shiraz Medical School - Department of Surgery, ايران , Kazemi, Kurosh shiraz university of medical sciences - Shiraz Medical School - Department of Surgery, ايران , MalekHosseini, Ali shiraz university of medical sciences - Shiraz Medical School, Transplant Research Center - Department of Pathology, Department of Surgery, ايران
Abstract :
The coincidence risk of autoimmune hepatitis (AIH) and hepatocellular carcinoma (HCC) in the absence of viral hepatitis is extremely low and most of the previous reports have been isolated case reports (1). Meanwhile, most of the previous cases have been reported before HCV screening and it is believed that some of them were secondary to HCV co-pathogenesis (2). Therefore, HCC is a rare sequel of AIH, and an incidence of about 1% has been reported from different geographic areas (3). Herein we report our experience in two female patients aged 35 and 39 with AIH and cirrhosis, who affected by HCC. Case No. 1 was diagnosed as AIH in 2005. She was admitted in the liver transplant list. Alpha-fetoprotein (AFP) level was 4.4 ng/mL (normal 5 ng/mL). Routine work up for the liver transplantation was started.
Keywords :
Hepatitis, Autoimmune , Carcinoma, Hepatocellular
