Vitamin D and cardiometabolic risk factors in adult non-diabetic offspring of type 2 diabetic parents

Objective: To measure serum vitamin D levels and assess its correlation with the various components of metabolic syndrome in adult non-diabetic offsprings of type 2 diabetics. Methods: The analytical cross-sectional study was conducted from February to December 2012 at the Department of Physiology and Cell Biology, University of Health Sciences, Lahore. Data on anthropometric and physiologic/biochemical parameters was collected. Fasting blood samples were collected and serum was analysed for fasting serum insulin, fasting blood sugar, lipid profile and vitamin D. SPSS 20 was used for statistical analysis. Results: Of the total 88 subjects in the study, 40(45.5%) were offsprings of type 2 diabetics and 48 (54.5%) were offsprings of non-diabetic parents. Vitamin D deficiency ( 20ng/ml) was observed in 86 (98.5%) of the subjects and 77 (87.5%) had vitamin D levels 15ng/ml. Severe deficiency ( 10ng/ml) was seen in 61 (70%) subjects. Inverse correlation was observed between vitamin D and low density lipoprotein, total cholesterol, total cholesterol/high density lipoprotein ratio, Fasting Blood Sugar and homeostasis model assessment of insulin resistance. Conclusion: The subjects were severely deficient in vitamin D and its levels were inversely correlated with most of the components of metabolic syndrome.