Author/Authors :
liang, kung-hao chang gung memorial hospital - liver research center, Taipei, Taiwan , yeh, chau-ting chang gung memorial hospital - liver research center, Taipei, Taiwan , yeh, chau-ting chang gung university - molecular medicine research center, Taoyuan, Taiwan
Abstract :
Osteopontin (OPN) is a growth regulatory protein for hepatocellular carcinoma (HCC) and apotent chemoattractant for macrophages. Zhu and colleagues recently reported significant clinical associationsbetween poor postoperative prognosis and the concurrent detection of tumoral OPN expression andperitumoral macrophage (PTM) infiltration. An in-depth understanding on the complex interaction betweentumoral OPN and macrophage-infiltrated microenvironment opens new doors to novel anticancer treatments.
Keywords :
Metastasis , cancer recurrence , inflammation , early detection
