• Title of article

    Predicting responsiveness to sorafenib: can the determination of FGF3/FGF4 amplifications enrich for clinical benefit?

  • Author/Authors

    harding, james j. memorial sloan kettering cancer center and weill cornell - medical college - department of medicine, New York, USA , abou-alfa, ghassan k. memorial sloan kettering cancer center and weill cornell - medical college - department of medicine, New York, USA

  • From page
    168
  • To page
    171
  • Abstract
    A small proportion of patients with advanced hepatocellular carcinoma harbor FGF3/4 geneamplifications in an 11q13 amplicon. A recent report suggests that the presence of this alteration mightenrich for sensitivity to sorafenib. Further, there is growing evidence that interference with the FGF/FGFRaxis has therapeutic potential in patients with advanced hepatocellular carcinoma.
  • Keywords
    Hepatocellular carcinoma (HCC) , fibroblast growth factor (FGF) , sorafenib , brivanib , targetedtherapy
  • Journal title
    Hepatobiliary Surgery an‎d Nutrition
  • Journal title
    Hepatobiliary Surgery an‎d Nutrition
  • Record number

    2654005

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2654005