Effect of glycerol in reduction of post-surgical adhesions in rat s model

This study was designed to investigate the role of glycerol in reducing of adhesions following surgery. Thirty Wistar albino male rats were randomly assigned into three groups; T 1 and T2, twelve rats for each, and six for control. Adhesion model was created in all rats. The rats in T1 were injected intraperitoneally with 5ml of glycerol 14.3%. Rats in T2 were injected intraperitoneally with 5ml of glycerol 28.6%. Rats in control groups were injected intraperitoneally with 5ml of sterile normal saline. All rats were scarified at postoperative day 14, and the gross macroscopic and microscopic score adhesions parameters were evaluated. The gross macroscopic adhesions were graded in a blind fashion, while the microscopic adhesions parameters (fibrosis, inflammation, and vascular proliferation) were gradedfrom 0-3. Adhesions were statisticallysignificantly in rats of the control group when compared to treatment groups (p≤0.01). In conclusion, this study reveals that intra peritoneal administration of glycerol (14.3%, and 28.6%) to serosal abrasions and caecotomies in rats has a role in reduction of intraabdominal adhesion formation after surgical manipulation.