Effect of Salvia Officinalis on the Histological Parameters and physiological creteria of Male Reproductive System in Mice

The present study aims to reveal the effect of Salvia officinalis in the physiological and histological state of male mice reproductive system. Fifteen adult males Swiss Albino mice at the age of two months were divided into three groups; the control group and the experimental group, which is subdivided into two groups. The first treated group received 0.03g/day extract of Salvia officinalis, the second was treated with 0.01g/day extract of Salvia officinalis for 30 days. Then, the animals were weighted and dissected to remove the testis for histological study. Also, the liver, kidney, heart, epididymis, prostate and spleen were removed from the animals and weighted. The study revealed an increase in body weight of animals treated with Salvia officinalis. There was a significant gradual increase in body weight (28.56, 31.88)g which was of direct proportion with the increase of the given dosages of the Salvia as compared with the control group 27.65g. The testis and epiddymis showed a clear increase in weight (0.14, 0.736, 0.298, 0.526)g which was statistically significant (P 0.05) and this increase was in direct proportion with the increase in the given dosages of Salvia when compared with the control group (0.116, 0.262)g. There was a significant increase (p 0.05) in the weight of the liver, spleen, kidney and prostate (1.68, 1.89, 0.256, 0.306, 0.454, 0.552, 0.206, 0.276)g as compared with the control group (1.44, 0.212, 0.436 and 0.176)g, respectively. Histological examination showed an increase in the number of layers in germinative epithelia of seminiferous tubules. On the other hand, results showed an increase in the number of sperms within the lumen in addition to an decrease in the diameter of tubules as compared with the control group and the activation of tubules epithelium increases with the increase of dose. These results highlight the role of Salvia officinalis in activating spermatogonia and the production of sperms.