Potensi Ekstrak Etanol Daun Petai (Parkia speciosa Hassk.) Terhadap Kadar Superoksida Dismutase (SOD) Pada Plasma Tikus yang Mengalami Stres Oksidatif

Cigarette smoke is free radicals superoxide resources that contains, hydrogen peroxide, hidrosiland peroksil. Superoxide dismutase (SOD) is an enzymatic antioxidants that protect cells fromoxidative stress by catalyzing superoxide dismutase (O2*) into O2 and H2O2. This study aims todetermine the potential of ethanolic extract petai leaves against plasma SOD enzyme activity inanimals exposed by cigarette smoke. The simplicia extracted by maseration using ethanol 96%.Thirty-six rats Sprague Dawley strain were divided into six groups: normal group was not giventreatment, negative group received 10% CMC-Na, positive control group received vitamin E,and treatment group received ethanolic extract petai leaves of 50; 100; 250 mg / kgBW of mice.All rats were treated for 14 days. SOD activity was measured by UV-Visible spectrophotometerat a wavelength of 505 nm. Statistical analysis using One Way ANOVA. The mean value of SODactivity to the normal, negative control, positive control and the group receiving the ethanolicextract petai leaves dose of 50; 100; 250 mg/kg in a row is 37 979 ± 3708; 59 932 ± 3085; 48 552± 1234; 57 239 ± 2102; 50 774 ± 1632; 59 124 ± 4849. The results show ethanolic extract petaileaves the most influence on the activity of SOD is a dose of 100 mg/kg.