Title of article :
Clear mortality gap caused by graft macrosteatosis in Chinese patients after cadaveric liver transplantation
Author/Authors :
liu, zhengtao zhejiang university - school of medicine, first affiliated hospital - department of surgery, division of hepatobiliary and pancreatic surgery, Hangzhou, China , liu, zhengtao zhejiang university - school of medicine, first affiliated hospital - key laboratory of organtransplantation of zhejiang province, Hangzhou, china , liu, zhengtao zhejiang university - school of medicine, first affiliated hospital - nhc key laboratory of combined multi-organ transplantation, key laboratory of the diagnosis and treatment of organ transplantation, Hangzhou, china , wang, wenchao zhejiang university - school of medicine, first affiliated hospital - department of surgery, division of hepatobiliary and pancreatic surgery, Hangzhou, China , wang, wenchao zhejiang university - school of medicine, first affiliated hospital - nhc key laboratory of combined multi-organ transplantation, key laboratory of the diagnosis and treatment of organ transplantation, Hangzhou, china , zhuang, li zhejiang shuren university - shulan international medical college, shulan (hangzhou)hospital, Hangzhou, China , que, shuping kth-royal institute of technology - science for life laboratory, Stockholm, Sweden , que, shuping dingxiang clinics, Hangzhou, China , zhu, dan zhejiang shuren university - shulan international medical college, shulan (hangzhou) hospital, Hangzhou, China , dong, linfang zhejiang shuren university - shulan international medical college, shulan (hangzhou) hospital, Hangzhou, China , yu, jian zhejiang university - school of medicine, first affiliated hospital - department of surgery, division of hepatobiliary and pancreatic surgery, Hangzhou, China , zhou, lin zhejiang university - school of medicine, first affiliated hospital - department of surgery, 1division of hepatobiliary and pancreatic surgery, Hangzhou, China , zhou, lin zhejiang university - school of medicine, first affiliated hospital - nhc key laboratory of combined multi-organ transplantation, key laboratory of the diagnosis and treatment of organ transplantation, Hangzhou, china , zhou, lin zhejiang university - school of medicine, first affiliated hospital - key laboratory of organtransplantation of zhejiang province, Hangzhou, china , zheng, shusen zhejiang shuren university - shulan international medical college, shulan (hangzhou) hospital, Hangzhou, China , zheng, shusen zhejiang university - school of medicine, first affiliated hospital - key laboratory of organtransplantation of zhejiang province, Hangzhou, china , zheng, shusen zhejiang university - school of medicine, first affiliated hospital - nhc key laboratory of combined multi-organ transplantation, key laboratory of the diagnosis and treatment of organ transplantation, Hangzhou, china , zheng, shusen zhejiang university - school of medicine, first affiliated hospital - department of surgery, division of hepatobiliary and pancreatic surgery, Hangzhou, China
From page :
739
To page :
758
Abstract :
Background: Liver transplantation (LT) is one of the most effective surgical treatment for patients with end-stage liver disease. Steatosis is a contributor for inferior graft quality. But its impact and safety on transplantation was less assessed in Chinese patients. Methods: Graft steatosis and related information involved in recipients, donors and surgical procedures were retrospectively collected from 239 patients. Results: Donor macrosteatosis (MaS) caused about 2.14 and 2.80 folds of increment on patient and graft mortality. Dose-response analysis revealed prominent risk of grafts on overall patient/organ mortality when MaS content exceeded 10% (P 0.05). Noteworthy, deaths were only observed in MaS group when concurrent with extremely higher post-transplant alanine aminotransferase (ALT, 64%). However, microsteatosis (MiS) grafts didn’t affect outcomes after LT. In a cohort of Chinese patients, MaS had comprehensive effects on post-transplant outcomes with relatively lower safety threshold at 10%. Mortality gap caused by MaS grafts was observed in patients with severer ischemia reperfusion injury. Conclusions: Our study revealled the graft MaS affected the post-transplant outcomes in lower risk cutoff in Chinese patients. Further study is worthy to validate these results and investigate inner mechanism under the phenomenon.
Keywords :
Steatosis , prognosis , liver transplantation (LT) , dose , response analysis
Journal title :
Hepatobiliary Surgery an‎d Nutrition
Journal title :
Hepatobiliary Surgery an‎d Nutrition
Record number :
2655350
Link To Document :
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