Synthesis, Characterization, and Antibacterial Evaluation of New N-Phenylnaphthalimides linked to Benzothiazole moiety

In this work several new naphthalimides linkd to substituted benzothiazole moiety were prepared. Preparation of the new naphthalimides was performed via multistep synthesis which include reacted of naphthalic anhydride with 4-aminobenzoic acid, then the product subsequently introduced in reaction with thionyl chloride producing 4-(N-naphthalimidyl) benzoyl chloride which in turn introduced in reaction with substituted benzothiazoles affording the target new naphthalimides. The prepared compound were screened for their antimicrobial activity against gram positive (Staphylococcus aureous, Streptococcus pyogenes), gram negative (Escherichia coli and Pseudomonas aureginosa) and yeast (Candida albicans). The results indicated that they exhibit good antimicrobial activity against the tested organism.