Synthesis and Antimicrobial Activity of Some New Imidazo[1,2-c]pyrimido[5,4:4,5]furo[2,3- e]Pyrimidine Derivatives

The present work was planned to synthesize some new heterocyclic compounds containing furo [2,3-e]pyrimidines, of anticipated biological and medicinal importance. A series of partially hydrogenated imidazo[1,2-c]pyrimido[5,4:4,5]furo[2,3-e]pyrimidine derivatives (3-8) have been synthesized from the o-aminonitrile 1 through the reaction with ethylene diamine and subsequent condensation of the resulting compound 2 with orthoester, carbon didulfide, and aromatic aldehydes. Also the triazolo derivatives (11-13) were achieved through the reaction of the 2- hydrazino-11-methyl–9-phenyl–4,5-dihydroimidazo[1,2-c]pyrimido[5,4:4,5]furo[2,3-e]pyrimidine (10) with some reagents such as: carbon disulfide, triethyl orthoformate and ethyl chloroformate . While the 11-methyl-2(3,5-dimethylpyrazol-1-yl)–9-phenyl–4,5-dihydroimidazo[1,2-c]pyrimido[ 5,4:4,5]furo[2,3-e]pyrimidine (14) was obtained by the refluxing of the hydrazino derivative 10 with acetyl acetone in ethanol. Finally, most of the synthesized compounds have been tested in vitro against some different species of bacteria and fungi.