Effect of fenugreek seeds and cinnamon bark aqueous extracts on liver and kidney functions in male diabetic rats

Trigonella foenum-graecum (Fenugreek) seeds and Cinnamomum zeylanicum (Cinnamon) bark have long been utilized for culinary purposes prior to being recognized as a hypoglycemic agents. Here we tested the hypothesis that administration of fenugreek seeds and cinnamon bark modulates the adverse effects of diabetes on blood glucose, liver enzymes and kidney functions of diabetes induced by alloxan in male rats by using their aqueous extracts. Induction of diabetes significantly increased the blood glucose associated with a significant depression in the activity of liver enzymes and kidney functions. The animals is divided into 6 groups each contains 6 rats: normal group, diabetic group, two diabetic groups treated separately with low dose and high dose of aqueous fenugreek extract and two diabetic groups treated separately with low dose and high dose of aqueous cinnamon extract. Compared with untreated diabetic group, there were a significant decrease in F.B.G., ALT, AST, ALP, Urea and Creatinine levels in treated diabetic rats after administration with extracts and that effects were depend on doses, and also cinnamon had better effects than fenugreek.